Immunmodulation in Patients With HHT

University Hospital Essen

Status: Completed

Conditions: Hereditary Haemorrhagic Telangiectasia (HHT)

Treatments: Other: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02983253

ImmunUHEssen

Details and patient eligibility

About

Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder. Literature suggests that HHT is often associated with higher frequency of infectious diseases.

The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.

Full description

Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder with recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. Literature and the investigators' observation suggest that HHT is often associated with higher frequency of infectious diseases. This might be a hint for a immunocompromised situation.

The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.

Enrollment: 124 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18 or over, HHT

Exclusion criteria

• Unable to provide informed consent

Trial design

124 participants in 2 patient groups

Patients with HHT

Description:

blood sample of patients with HHT

Treatment:

Other: blood sample

probands

Description:

blood sample of healthy controls

Treatment:

Other: blood sample