Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study (NEUTROSURGERY)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Begins enrollment in 6 months

Conditions: Ischemic Cerebrovascular Accident

Treatments: Procedure: Decompressive hemicraniectomy; Procedure: neurosurgical operation

Study type: Observational

Funder types: NETWORK

Identifiers

NCT04763161

BMR_2021_2

Details and patient eligibility

About

The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Patients:

• Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC.

Inclusion Criteria Control:

- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.

Non-inclusion Criteria Patients:

• HD carried out in a context of acute cerebral haemorrhage
• Pre-existing neurological disability: modified Rankin score > 2
• Patient benefiting from a legal protection measure

Non-inclusion Criteria Controls:

• Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage.
• Patient operated on for an osteomeningeal pathology present at the approach site.
• Patient operated on for an infectious cranial or neuro-meningeal pathology.
• Patient to be operated on as a result of an intracranial traumatic condition

Trial design

90 participants in 2 patient groups

Experimental group

Description:

Patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy. Intervention is decompressive hemicraniectomy in the context of a malignant sylvian ischaemic cerebral

Treatment:

Procedure: Decompressive hemicraniectomy

Control group

Description:

Patients not suffering from AIC, hospitalised in neurosurgery for another reason, Patients to be opered on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.

Treatment:

Procedure: neurosurgical operation