Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage (FluBAL)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Influenza; Acute Respiratory Distress Syndrome; Acute Lung Injury

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01089400

C09-39

Details and patient eligibility

About

The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals. The respective roles of viral replication, bacterial infection and immune alterations of the host during such severe influenza H1N1v infection need to be clarified in order to optimize patients care. In this context, we aim to study immune and virological parameters in bronchoalveolar lavage fluid during severe influenza A/H1N1v infection with pulmonary involvement in intensive care unit. Results will be correlated to bacterial or viral pulmonary co-infections and to peripheral blood immune and virological parameters.

Enrollment: 30 patients

Sex: All

Ages: 13+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected influenza A/H1N1 infection
• Diffuse bilateral pneumonia <96h with acute lung injury or respiratory distress syndrome
• Invasive or non-invasive ventilation in intensive care unit
• Age > 13

Exclusion criteria

• Other cause identified of acute lung injury or acute respiratory distress syndrome
• Contraindicated bronchoalveolar lavage

Trial design

30 participants in 2 patient groups

Influenza A/H1N1 patients

Non influenza A/H1N1 patients