Immunocompetent Versus Immunocompromised Tuberculosis (TB) Patients

Sohag University

Status: Not yet enrolling

Conditions: Tuberculosis

Treatments: Diagnostic Test: zeihl - Nelsen stain; Diagnostic Test: Molecular detection of antibiotic resistance; Diagnostic Test: P24 antigens and antibody; Diagnostic Test: culture on Lowenstein jensen media

Study type: Observational

Funder types: Other

Identifiers

NCT06709157

Soh-Med-24-08--05PD

Details and patient eligibility

About

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the top 10 causes of mortality worldwide. It is estimated that in 2017, 10 million people were infected with TB, and 1.6 million died from the disease, including 0.3 million people with human immunodeficiency virus (HIV) infection . TB remains the primary killer of HIV-positive individuals. TB incidence is falling at about 2% per year . Airborne transmission of M. tuberculosis typically causes TB infection in both immunocompetent and immunocompromised hosts and the disease is symptomatic and contagious .

Full description

TB and HIV infections are strictly linked together. TB is the most common opportunistic infection and causes high morbidity rate among people living with HIV. Because of the decrease in cell-mediated immunity, HIV alters the pathogenesis of TB, thereby expressively increasing the risk of TB in HIV-positive patients and eventually leading to more severe complications and forms of TB.

Enrollment: 200 estimated patients

Sex: All

Ages: 16 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chronic chest disease

Exclusion criteria

• Patients with other respiratory or infectious diseases.