Immunodeficiency in MS

Advanced Neurosciences Institute

Status: Unknown

Conditions: Immunodeficiency; Hypogammaglobulinemia; Multiple Sclerosis; Infection, Bacterial

Treatments: Other: No Interventions

Study type: Observational

Funder types: Other

Identifiers

NCT04447937

NPI-110

Details and patient eligibility

About

The purpose of this study is to identify if there is a relationship between multiple sclerosis disease-modifying therapy exposure, immunodeficiencies, and infection risk in subjects living with MS.

Full description

The purpose of this study is to identify if there is a relationship between multiple sclerosis disease-modifying therapy exposure, immunodeficiencies, and infection risk in subjects living with MS. By understanding this relationship future studies can be designed to create a model of immunosenescence in multiple sclerosis, which could help healthcare providers to predict and assess health risks. Preventative strategies can then be tested to look for ways to prevent these immune-related risks.

Enrollment: 1,500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• One or more immunoglobulin level results and medical history available
• 18 years of age or older at the time of data collection
• Patients with first symptom MS or other isolated demyelinating syndromes, neuromyelitis optica, or rheumatic-associated CNS inflammation

Exclusion Criteria:

• No evidence of CNS autoimmune disease
• Less than 18 years of age at the time of data abstraction
• Undergoing plasma exchange at the time of any lab tests drawn

Trial design

1,500 participants in 1 patient group

Multiple Sclerosis and Related Diseases

Description:

Individuals with one or more immunoglobulin level results and medical histories available for data collection will be included. Subjects will be 18 years of age or older at the time of data collection.

Treatment:

Other: No Interventions