Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care (CHORDOMES)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Chordoma

Treatments: Other: Analysis Immunohistochemical

Study type: Observational

Funder types: Other

Identifiers

NCT04486820

20CH028

Details and patient eligibility

About

Chordomas are very rare malignant tumors, chemo-resistant with high propensity for recurrence. The role of immunotherapy in these patients remains largely unexplored while PD-L1 and CD8 status in the micro-environment of chordomas is basically not known. Similarly, this tumor often poses diagnostic difficulties due to its resemblance with metastasis or chondrosarcoma, thus, it would be useful to know the expression status of factors used during the work-up of metastatic or mesenchymal tumors, like CDX2, INSM1 and FOXA1, which remains unknown for chordomas. Thus, the aim of the study is to explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression in a series of chordomas and compare it with clinico-pathological and prognostic features.

Full description

Retrospective, non-interventional study. A series of chordomas will be analyzed for detailed histologic features and for various immunohistochemical factors and results will be compared with clinical factors, like overall and disease-free survival.

Enrollment: 40 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with chordoma
• Sufficient histological material available
• Tumor expression of brachyury

Exclusion criteria

• Insufficient histological material

Trial design

40 participants in 1 patient group

Chordoma

Description:

Patients diagnosed with chordoma

Treatment:

Other: Analysis Immunohistochemical