Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection (MRSA-2)

H

Henry M. Jackson Foundation for the Advancement of Military Medicine

Status

Completed

Conditions

Staphylococcal Infections
HIV Infections

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT00859677
IDCRP -023

Details and patient eligibility

About

The purpose of this study is to investigate the role of T helper 17 cells (Th17) in the pathogenesis of MRSA infections.

Enrollment

52 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

All participant inclusion criteria:

  • Greater or equal to 18 years of age
  • Willingness to undergo blood draw. Skin biopsy will be requested, but is optional

-AND-

HIV-positive and MRSA-negative Group:

  • Documented positive HIV test result
  • Negative colonization swabs for S. aureus within 14 days of enrollment
  • No evidence of skin/soft tissue infection

HIV-positive and MRSA-Colonization Group:

  • Documented positive HIV test result
  • History of of colonization with MRSA w/in 14 days of study enrollment

HIV-positive and MRSA Infection Group:

  • Documented positive HIV test result
  • Skin/soft tissue infection with a positive wound culture showing MRSA within 7 days of enrollment
  • MRSA infection is not associated with an intravenous catheter or other nosocomial procedure

HIV Negative groups:

  • Same criteria used for the HIV-negative groups as listed above.
  • No history of HIV infection.
  • Willing to undergo an HIV blood test, which must have a negative result.

Exclusion Criteria:

  • Women with positive urine pregnancy test within 7 days of study enrollment
  • Women who are within 6 months of being postpartum or who are currently breastfeeding
  • Subjects unable or unwilling to complete questionnaires and blood draw.

Trial design

52 participants in 6 patient groups

1
Description:
HIV-positive and MRSA negative
2
Description:
HIV-positive and MRSA infected (skin/soft tissue)
3
Description:
HIV-positive and MRSA colonized
4
Description:
HIV-negative and MRSA negative
5
Description:
HIV-negative and MRSA infected (skin/soft tissue)
6
Description:
HIV-negative and MRSA colonized

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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