Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection (MRSA-2)

Henry M. Jackson Foundation for the Advancement of Military Medicine

Status: Completed

Conditions: Staphylococcal Infections; HIV Infections

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00859677

IDCRP -023

Details and patient eligibility

About

The purpose of this study is to investigate the role of T helper 17 cells (Th17) in the pathogenesis of MRSA infections.

Enrollment: 52 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

All participant inclusion criteria:

• Greater or equal to 18 years of age
• Willingness to undergo blood draw. Skin biopsy will be requested, but is optional

-AND-

HIV-positive and MRSA-negative Group:

• Documented positive HIV test result
• Negative colonization swabs for S. aureus within 14 days of enrollment
• No evidence of skin/soft tissue infection

HIV-positive and MRSA-Colonization Group:

• Documented positive HIV test result
• History of of colonization with MRSA w/in 14 days of study enrollment

HIV-positive and MRSA Infection Group:

• Documented positive HIV test result
• Skin/soft tissue infection with a positive wound culture showing MRSA within 7 days of enrollment
• MRSA infection is not associated with an intravenous catheter or other nosocomial procedure

HIV Negative groups:

• Same criteria used for the HIV-negative groups as listed above.
• No history of HIV infection.
• Willing to undergo an HIV blood test, which must have a negative result.

Exclusion Criteria:

• Women with positive urine pregnancy test within 7 days of study enrollment
• Women who are within 6 months of being postpartum or who are currently breastfeeding
• Subjects unable or unwilling to complete questionnaires and blood draw.

Trial design

52 participants in 6 patient groups

1

Description:

HIV-positive and MRSA negative

2

Description:

HIV-positive and MRSA infected (skin/soft tissue)

3

Description:

HIV-positive and MRSA colonized

4

Description:

HIV-negative and MRSA negative

5

Description:

HIV-negative and MRSA infected (skin/soft tissue)

6

Description:

HIV-negative and MRSA colonized