Immunological Change and the Single Nucleotide Polymorphism (SNP) in Children With Irritable Bowel Syndrome (IBS)

Chang Gung Medical Foundation

Status: Unknown

Conditions: Irritable Bowel Syndrome; Children

Study type: Observational

Funder types: Other

Identifiers

NCT01131442

CMRPG270371

Details and patient eligibility

About

Currently, the pathophysiology of Irritable bowel syndrome( IBS) remains unclear . The purpose of this study is want to investigate the immunological changes in the children with IBS.

Full description

Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder.Many children suffered from this disease and had impact on their daily life. However, the underlying pathophysiologic mechanisms remain to be elucidate. Dysregulation of the gut immune system is considered an important pathophysiology. We want to investigate the immunological changes in the IBS children.

Enrollment: 40 estimated patients

Sex: All

Ages: 5 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• (5-18y/o) with IBS,
• All patients had chronic or relapsing symptoms of IBS consistent with the ROME II criteria

Exclusion criteria

• A history of psychologic disorders, probiotics, anti-inflammatory, analgesic, or immunosuppressive medication (nonsteroidal anti-inflammatory drugs, steroids) within the past 3 months were excluded

Trial design

40 participants in 2 patient groups

The patient group

healthy control group