Immunological Profile of Solid Tumors Sample

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Unknown

Conditions: Solid Cancer

Treatments: Other: immunohistochemistry assay

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03311100

2017-A00778-45 (Registry Identifier)

2016-53

Details and patient eligibility

About

It has become clear in the recent year that the nature of the immune cells infiltrate within a tumor was essential in the control of the tumor growth. This so-called immune contexture does vary between cancer types and in response to treatments. In this context, this trial is a non-interventional, mono-centric in patients with solid tumors. Samples in paraffin-embedded material block of biopsies or surgical pieces (either primitive tumor or metastases) will be analysed. For each sample, clinically relevant data associated with treated cancer and needed for characterization of tumor microenvironment will be documented.

This trial is, through accessing to well documented selected archival tumor materials, to validate selected biomarker for early phase trial.

Enrollment: 1,040 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sample must have had a valid written informed consent for available archival tumor samples for scientific purposes.
• Sample from patients with histologically documented cancer in target population.

Exclusion criteria

• Samples from subject unwilling to give their informed consent;
• Unusable sample or biologically deteriorated.

Trial design

1,040 participants in 7 patient groups

Lung cancer

Treatment:

Other: immunohistochemistry assay

Central Nervous System Cancers

Treatment:

Other: immunohistochemistry assay

Head and Neck and upper aero-digestive tract cancers

Treatment:

Other: immunohistochemistry assay

Skin cancers

Treatment:

Other: immunohistochemistry assay

Sarcomas

Treatment:

Other: immunohistochemistry assay

Urothelial cancer

Treatment:

Other: immunohistochemistry assay

Hepatocarcinoma

Treatment:

Other: immunohistochemistry assay