Immunological Response After Shrimp Oral Immunotherapy Treatment

Mahidol University

Status

Completed

Conditions

Immunotherapy

Allergy to Shrimp

Treatments

Other: shrimp allergy with intend to eat shrimp

Study type

Interventional

Funder types

Other

Identifiers

NCT04552522

090/2563

Details and patient eligibility

About

Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.

Full description

All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.

Enrollment

20 patients

Sex

All

Ages

12 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 12 - 40 years old
History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life
Positive oral food challenge test for shrimp

Exclusion criteria

History of shrimp anaphylaxis (include cardiovascular or neurological symptoms)
Shellfish dependent exercise induced anaphylaxis
History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis
History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker