Immunological Tolerance After Frequent Rabies Booster Vaccinations

Queen Saovabha Memorial Institute

Status: Unknown

Conditions: Rabies

Treatments: Biological: Blood drawn after rabies vaccine booster vaccination

Study type: Interventional

Funder types: Other

Identifiers

NCT03729102

QSMI-IRB 2/2018

Details and patient eligibility

About

To study immunological tolerance effect after frequent rabies booster vaccination

Full description

Previous studies had shown lower antibody titers among those who received frequent rabies booster vaccination, compared to ones who had got primary immunization. We study immunological cells i.e., regulatory T cell, regulatory B cell, T follicular helper cell, and cytokines in those who received frequent rabies booster vaccination.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults
• Previously received rabies vaccination

Exclusion criteria

• Had immunocompromised conditions
• Received blood or blood product within 3 months
• Received anti-malarial drugs

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Control group

Active Comparator group

Description:

Persons who had received primary immunization

Treatment:

Biological: Blood drawn after rabies vaccine booster vaccination

Study group

Experimental group

Description:

Persons who had received primary immunization and later received booster vaccination for at least 3 times

Treatment:

Biological: Blood drawn after rabies vaccine booster vaccination