Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

Chulalongkorn University

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Procedure: Continuous renal replacement therapy with regional citrate anticoagulation; Procedure: Continuous renal replacement therapy with no anticoagulation or heparin

Study type: Interventional

Funder types: Other

Identifiers

NCT02423642

IRB.136/56

Details and patient eligibility

About

The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).

Enrollment: 30 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Systemic inflammatory response syndrome; SIRS > or = 2 meets definition
• Patients with acute kidney injury in the intensive care ward.
• Requiring continuous renal replacement therapy.

Exclusion criteria

• Pregnancy
• Cirrhosis
• End stage renal disease
• HIV infection
• Serum creatinine in male > 2 mg/dl and female > 1.5 mg/dl
• Bleeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

AKI requring CRRT and use regional citrate anticoagulation

Experimental group

Description:

CRRT use regional citrate anticoagulation

Treatment:

Procedure: Continuous renal replacement therapy with regional citrate anticoagulation

AKI requring CRRT and not use regional citrate anticoagulation

Experimental group

Description:

CRRT not use regional citrate anticoagulation

Treatment:

Procedure: Continuous renal replacement therapy with no anticoagulation or heparin