Immunomodulatory Effects of Dexmedetomidine Infusion

Alexandria University

Status: Unknown

Conditions: Major Abdominal Surgery

Treatments: Drug: Dexmedetomidine; Drug: 0.9% sodium chloride

Study type: Interventional

Funder types: Other

Identifiers

NCT04923737

0304767

Details and patient eligibility

About

Anesthetic management may affect both immunostimulatory and immunosuppressive mechanisms directly by modulating immune cell function or indirectly by attenuating the stress response, Thus, the choice of anesthetic technique may affect clinical outcomes by perturbing the balance between pro- and anti-inflammatory responses,anesthetics favoring this delicate balance are thus desirable as their use may reduce postoperative complications and mortality

Enrollment: 100 estimated patients

Sex: All

Ages: 25 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• scheduled for elective laparoscopic major abdominal surgeries;
• ASA class II-III

Exclusion criteria

• 1- Patients with severe infection or diseases in respiratory system 2- Patients with severe arrhythmia or bradycardia 3- Patients with severe diseases in liver, kidney, endocrine or immune system. 4- Patients with history of uncontrolled hypertension, A-V conduction block. 5- Patients who had administrated the α-adrenergic agonists or β-receptor antagonist.

6- Patients who received the chemotherapy, radiotherapy, or immunotherapy within one month before operation 7- Patients who had feverbefore operation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Dexmedetomidine group

Active Comparator group

Description:

patients will receive a loading dose of IV Dexmedetomidine1μg/kg slowly just before induction of anesthesia, then Dexmedetomidine infusion started at a rate of 0.5μg/kg/h.

Treatment:

Drug: Dexmedetomidine

Control group

Placebo Comparator group

Description:

patients will receive an equal volume of 0.9% sodium chloride (both the loading, and the infusion

Treatment:

Drug: 0.9% sodium chloride