Immunomonitoring of Interventional Radiology Procedures in the Management of Hepatocellular Carcinoma (PAI²HCC)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Hepatocellular Carcinoma

Treatments: Procedure: Percutaneous ablation

Study type: Observational

Funder types: Other

Identifiers

NCT04892810

Grenoble University Hospital

Details and patient eligibility

About

This cohort study compares immune response induced in two groups of small HCC patients treated by ablation (group1 RFA, group 2 MWA). Patients will benefit for tumoral and non tumoral biopsies prior to treatment and stepped peripheral blood samples juste before ablation and during the first month after.

Enrollment: 20 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven HCC for less than 3 months before ablation
• Decision of ablation treatment in multidisciplinary meeting

Exclusion criteria

• Fibrolamellar HCC
• Hepatocholangiocarcinoma

Trial design

20 participants in 2 patient groups

RFA

Description:

Patient with HCC and decision of treatment with ablation

Treatment:

Procedure: Percutaneous ablation

MWA

Description:

Patient with HCC and decision of treatment with ablation

Treatment:

Procedure: Percutaneous ablation