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Immunopathologic Profiles and Blood Biomarkers in Patients With IPF

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University of Aarhus

Status

Completed

Conditions

Idiopathic Pulmonary Fibrosis

Study type

Observational

Funder types

Other

Identifiers

NCT04187079
Cryobiopsy in IPF

Details and patient eligibility

About

Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other interstitial lung diseases.

Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Full description

Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in blood samples in patients with IPF compared with other interstitial lung diseases.

Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Enrollment

100 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients suspected of having an ILD who are having cryobiopsies performed

Exclusion criteria

  • BMI > 35
  • DLCO < 35%
  • FVC < 45%
  • Pulmonary hypertension
  • Cardiac or other severe comorbidity that will increase the risk of complications

Trial design

100 participants in 2 patient groups

IPF
Description:
Patients diagnosed with idiopathic pulmonary fibrosis after multidisciplinary team discussion using medical history, HRCT pattern, laboratory findings, pulmonary function tests and cryobiopsy specimens.
Other ILDs
Description:
Patients diagnosed with other interstitial diseases other than IPF after multidisciplinary team discussion using medical history, HRCT pattern, laboratory findings, pulmonary function tests and cryobiopsy specimens.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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