Immunophenotyping of Patients With Postoperative SIRS

University of Bonn

Status: Unknown

Conditions: Systemic Inflammatory Response Syndrome

Treatments: Other: Immunophenotyping

Study type: Observational

Funder types: Other

Identifiers

NCT02957175

BOST-001

Details and patient eligibility

About

The purpose of this study is to develop an immune-phenotype based prediction of postoperative SIRS in patients undergoing open heart surgery.

Full description

The study will have a pre-, intra and postoperative phase in which several demographic and clinical variables will be assessed. The samples for the immunophenotypic analysis will be drawn directly after induction of anesthesia and at various time points after end of surgery. The diagnosis of SIRS will be made during routine clinical visits on the first seven postoperative days using the Sepsis-related Organ Failure Assessment score (SOFA-score). The patients will be followed up for 30 days.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Informed consent of the patient
• Patient undergoing a open heart surgery using a cardiopulmonary bypass

Exclusion criteria

• Age < 18 years
• Missing informed consent
• Renal failure
• Liver failure
• Neurodegenerative disease
• Malignancies
• Immune therapy

Trial design

50 participants in 2 patient groups

Patients that develop SIRS

Description:

Immunophenotyping of patients that develop SIRS after heart surgery

Treatment:

Other: Immunophenotyping

Patients that develop no SIRS

Description:

Immunophenotyping of patients that develop no SIRS after heart surgery

Treatment:

Other: Immunophenotyping