IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Critical Illness Requiring Intensive Care - Sepsis; Critical Illness Requiring Intensive Care - Polytrauma; Critical Illness; Intensive Care Patients; Critical Illness Requiring Intensive Care - Acute Brain Injury; Critical Illness Requiring Intensive Care - Major Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT07345169

2025-A00002-47 (Other Identifier)

APHP250001

Details and patient eligibility

About

This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections.

Patients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).

Enrollment: 540 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Admission to ICU within 24 hours

Exclusion criteria

• Moribund patient (ECOG=4)
• Legal protection (guardianship/curatorship)
• Uninsured patients
• Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV)
• Pregnant or breastfeeding women
• Participation in another interventional trial
• Patients under AME