Immunosuppressive Therapy Optimization: Development of a Population Pharmacokinetic-pharmacodynamic (PK-PD) Model in Liver Transplantation (OPTILTH)

Rennes University Hospital

Status: Completed

Conditions: Liver Transplantation

Treatments: Other: Pharmacokinetic-pharmacodynamic model in liver transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT02877628

35RC13_8962_OPTILTH

Details and patient eligibility

About

Prospective, non-randomized, open Pharmacokinetic-Pharmacogenetic-Pharmacodynamic monocentric study. Donor and recipient CYP3A5 genotype and recipient ABCB1 will not be communicate to clinicians or patients during the study.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults over 18
• Liver transplant recipients
• Treated with an immunosuppressive protocol with tacrolimus
• Informed on the study and who did not refuse to participate

Exclusion criteria

• Patients who participate in a study with procedures incompatible with the present study.
• Patients with legal protection/deprived of liberty.