Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer (FLUORIB)

Léon Bérard Center

Status

Withdrawn

Conditions

Cancer of Colon

Metastasis to Liver

Treatments

Procedure: Scheduled and planned surgery

Study type

Observational

Funder types

Other

Identifiers

ET 19-127 FLUORIB

Details and patient eligibility

About

Analyze the dynamics of incorporation of 5-fluorouracil into cancer cell ribosomes from liver metastases of patient with metastatic colon cancer.

Full description

This is a monocentric, prospective, non-interventional cohort study in adult patients with metastatic colon cancer with hepatics metastasis.

Tumour samples collected for this study include:

A fragment of the previously operated primary tumor: FFIP block and/or archived frozen tumor if available.
A fragment of the liver metastasis(s) performed as part of standard metastasis surgery, this fragment will include a tumor area and a healthy area within the margin of excision. These samples collected in a fresh state will be analyzed immediately.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient with metastatic colon cancer operated on and followed up at the Centre Leon Berard for liver metastasis.
Patient affiliated to social security

Exclusion criteria

Other pathologies that may interfere with biological evaluation, in particular known hepatic cirrhosis, whatever its origin, other liver overload diseases (hemochromatosis, Wilson's disease), but excluding steatosis (which can be chemo-induced).