Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment (MExeProMCI)

University of Patras

Status: Enrolling

Conditions: Balance; Mild Cognitive Impairment; Cognition; Walking

Treatments: Other: Innovative therapeutic exercise program; Other: Therapeutic exercise program; Other: Flyer

Study type: Interventional

Funder types: Other

Identifiers

NCT07334392

17335/01-06-2025

Details and patient eligibility

About

The goal of this randomised clinical trial is to investigate the effectiveness of an innovative therapeutic exercise program emphasizing in dual-task exercises in people with amnestic Mild Cognitive Impairment. The main questions it aims to answer are:

Does the innovative therapeutic exercise program improve gait and balance? Does the innovative therapeutic exercise program improve cognition?

Researchers will compare the innovative therapeutic exercise program emphasizing in dual-task exercises to a therapeutic exercise program without emphasizing in dual-task exercises and to a control group (given instruction about the benefits of exercise).

Participants will:

• Perform the exercise program twice a week for three months.
• Will be assessed before and after the intervention.
• Will record The Borg Scale of Perceived Exertion every second week to monitor and assess the progression of exercise intensity.

Enrollment: 45 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• individuals > 50 years old
• people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) >20
• stable medication in the last month
• independent walking

Exclusion criteria

• people with dementia
• people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder)
• people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury)
• people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis)
• people who have had recent surgery
• people with insufficient knowledge of the Greek language

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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45 participants in 3 patient groups

Innovative therapeutic exercise program emphasizing in dual tasking

Experimental group

Description:

Participants will perform aerobic exercises, strengthening exercises and balance exercises combined with cognitive exercises at the same time for 60- 90 minutes/ twice a week/ three months.

Treatment:

Other: Innovative therapeutic exercise program

Therapeutic exercise program

Active Comparator group

Description:

Participants will perform aerobic exercises, strengthening exercises and balance exercises for 60- 90 minutes/ twice a week/ three months.

Treatment:

Other: Therapeutic exercise program

Control group

Active Comparator group

Description:

The control group will be provided with educational material in the form of a flyer outlining the health benefits of exercise and general lifestyle recommendations.

Treatment:

Other: Flyer