Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)

The University of Chicago

Status: Completed

Conditions: Sleep Restriction

Treatments: Other: Sleep restriction

Study type: Interventional

Funder types: Other

Identifiers

NCT00817700

5P01AG011412 (U.S. NIH Grant/Contract)

#13159A

Details and patient eligibility

About

This project has 6 aims.

1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Enrollment: 72 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal weight
• healthy
• age 18-75 old

Exclusion criteria

• sleep disorder
• irregular life habits (shift workers, travelers)
• smokers
• on medication
• consumption of > 2 alcohol or caffeinated beverages/day

Trial design

72 participants in 2 patient groups

Normal (8 hours) sleep time

No Intervention group

Description:

Subjects are studied under normal sleep time conditions.

Sleep restriction

Experimental group

Description:

Sleep restriction to 4 hours of sleep per night. Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.

Treatment:

Other: Sleep restriction