Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults

Odense University Hospital

Status: Completed

Conditions: Hospitalisation; Physical Performance; Gait Speed; Resistance Training; Older Adults; Acutely Ill; Muscle Architecture; Functional Decline; Sarcopenia; Ultrasound

Treatments: Other: Resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT05798169

ARTMAP

Details and patient eligibility

About

Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.

Enrollment: 274 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≥65 years of age
• Able to ambulate before hospitalization (with/without assistance)
• Able to communicate with the research team
• Expected length of stay ≥2 days
• Residing on Funen

Exclusion criteria

• Able to ambulate without assistance during current hospitalization
• Known severe dementia
• Positive Confusion and Assessment Method score
• Patients who have received less than 3 resistance training sessions at discharge
• Terminal illness
• Recent major surgery or lower extremity bone fracture in the last 3 months
• Conditions contradicting use of ROBERT(unstable vertebral-, pelvic, or lower extremity fractures
• high intracranial pressure
• pressure ulcers or risk of developing pressure ulcers due to fragile skin
• patients with medical instability)
• Metastases at femur hip
• Deemed not suitable for resistance training sessions with the robot by the healthcare professional.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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274 participants in 2 patient groups

Intervention Group

Experimental group

Description:

Group of participants receiving resistance training during hospitalisation

Treatment:

Other: Resistance training

Control Group

Sham Comparator group

Description:

Group of participants receiving sham training during hospitalisation

Treatment:

Other: Resistance training