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Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis

K

Kangbuk Samsung Hospital

Status

Unknown

Conditions

Cirrhosis
Frailty
Kidney Injury
Sarcopenia

Study type

Observational

Funder types

Other

Identifiers

NCT05389280
KBSMCLC2022

Details and patient eligibility

About

The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.

Full description

The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status [RFH-NPT], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.

Enrollment

80 estimated patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Liver cirrhosis
  • aged over 20 years

Exclusion criteria

  • serum creatinine >1.5 mg/dL
  • on dialysis
  • liver transplant

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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