Impact of Adding Midzolam to Bupavicaine 0.5% in Regional Spinal Anaesthesia on Maternal Middle Cerebral Artery Velocimetry in Parturients With Severer Preeclampsia

Minia University

Status: Unknown

Conditions: Midazolam in Preeclamptic Patients

Treatments: Drug: intrthecl midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT04283110

293:9/2019

Details and patient eligibility

About

Trial to use GABA mimetic action of midazolam to ameliorate the severe preeclampsia induced neuronal excitotoxicity using middle cerebral artery transcranial doppler resisitive vasculer indices to evaluate . Secondery goal is to study end organ injury

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All parturients with severe preeclampsia for urgent C.S

Exclusion criteria

• Ladies refusal to participate. Refusal to have spinal anesthsia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Midazolam group

Active Comparator group

Description:

Midazolam group will receive 1 mg intrathecal midazolam once during induction for anethesia

Treatment:

Drug: intrthecl midazolam

control group

No Intervention group

Description:

control group will receive placebo ( 0.5cm of sterile saline