Impact of Admission SOFA Score and 48-hour Delta SOFA on Clinical Outcomes in Critically Ill Patients

Hospital Sao Domingos

Status: Completed

Conditions: Critically Ill Patients

Treatments: Other: Intervention focused on identified organ dysfunction(s)

Study type: Observational

Funder types: Other

Identifiers

NCT04980274

51

Details and patient eligibility

About

Organ dysfunctions are associated with high morbidity and mortality. The SOFA (Sequential Organ Failure Assessment) score developed by Vincent et al. sequentially assesses the presence and severity of dysfunctions in six organ systems: respiratory, cardiovascular, coagulation, hepatic, neurological and renal. Although the SOFA score was created to quantify organ dysfunctions, the obvious relationship between organ dysfunctions and mortality has been widely documented. Dynamic measurements of the SOFA score assess response to treatment and can be used to search for perpetuating sources of severity and reassess the treatment plan.

The primary objective of this study will be to assess the impact of an admission SOFA score equal to or greater than 2 and subsequent interventions on outcomes related to the 48-hour delta SOFA on ICU and hospital mortality, length of stay in the ICU, duration of mechanical ventilation, time of vasoactive drug use.

Patients will be divided into three groups: those who did not trigger the SOFA trigger on admission to the ICU (Group 1), those who triggered the SOFA trigger and improved on the third day (Group 2) and, finally, those who triggered the SOFA trigger and worsened on the third day (Group 3).

Enrollment: 1,410 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Included all patients over 18 years old admitted to the ICU during the study period

Exclusion criteria

• Excluded were patients who remained in the ICU for a period of less than 48 hours and pregnant women

Trial design

1,410 participants in 3 patient groups

Group 1

Description:

Patients with SOFA score \< 2 on admission

Treatment:

Other: Intervention focused on identified organ dysfunction(s)

Group 2

Description:

Patients with SOFA score equal to or \> 2 on admission and who improved after 48 hours of treatment

Treatment:

Other: Intervention focused on identified organ dysfunction(s)

Group 3

Description:

Patients with SOFA score equal to or \> 2 on admission and who did not improve after 48 hours of treatment

Treatment:

Other: Intervention focused on identified organ dysfunction(s)