Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension (IMPROVEH)

University of Copenhagen

Status: Completed

Conditions: Hypertension,Essential

Treatments: Other: Training

Study type: Interventional

Funder types: Other

Identifiers

NCT03778489

PANX-HYP

Details and patient eligibility

About

Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

Enrollment: 30 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sedentary men and women age 35 - 65 years
• Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg
• Essential hypertension
• Non or exclusively antihypertensive medication

Exclusion criteria

• Hypertensive condition other than essential hypertension
• Other chronical diseases
• Smoking
• Excess alcohol intake or drug abuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

30 participants in 2 patient groups

Hypertensive

Experimental group

Description:

Men and women in age-group 35-65 years Resting blood pressure of \>140/90 mmHg non or only anti-hypertensive medication

Treatment:

Other: Training

Control

Active Comparator group

Description:

Men and women in age-group 35-65 years Resting blood pressure of \<140/90 mmHg no medication

Treatment:

Other: Training