Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis

Faculdade de Ciências Médicas da Santa Casa de São Paulo

Status: Completed

Conditions: Adolescent Scoliosis; Scoliosis

Treatments: Device: treadmill; Other: combined exercise; Other: aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02413788

Fcmscsp

Details and patient eligibility

About

Inflammatory markers have been analyzed in several diseases of unknown etiology, in the expectation of increasing therapeutic perspectives. This possibility arises from the different levels of tissue injury with low-grade chronic inflammation that have been observed in studies in which the markers were not evaluated traditionally, and today have influenced clinical management.

The investigators aimed, therefore, to evaluate the inflammatory markers in patients with AIS before and after aerobic and combined exercise training.

Full description

Inflammatory markers have not been evaluated in adolescent idiopathic scoliosis (AIS), but this deformity potentially involves various musculoskeletal structures permanently, which justifies the analysis. A low-grade chronic inflammation may be related to the lower capacity in exercise performance observed in this population, which must be stimulated to perform standardized physical activity.

Enrollment: 40 patients

Sex: All

Ages: 10 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thoracic curvature ≥ 45 degrees
• indication for surgical treatment of spinal deformity
• absence of pulmonary, cardiac, articular or neurological disorder, atopic dermatitis and previous or current allergy
• agree part in the research with a assent statement and the person responsible with the consent form and informed

Exclusion criteria

• acknowledged chronic liver or kidney inflammatory disease
• use of corticosteroids, acetylsalicylic acid or other nonhormonal anti-inflammatory clinical or laboratorial evidence of infection
• severe obesity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

combined group (treadmill and resisted)

Experimental group

Description:

- 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) and resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs (36 sessions)

Treatment:

Device: treadmill

Other: combined exercise

aerobic group (treadmill)

Active Comparator group

Description:

10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) for 36 sessions

Treatment:

Device: treadmill

Other: aerobic exercise