Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study (OBSTETRICON)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Pregnancy Complications

Treatments: Other: loop electrosurgical excision procedure

Study type: Observational

Funder types: Other

Identifiers

NCT05765188

PI2017_843_0049

Details and patient eligibility

About

The maternity ward attached to the colposcopy clinic was also the obstetrical referral center for the region and carried out approximately 2500 deliveries per year. The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of the loop electrosurgical excision procedure (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.

Full description

The investigators conducted a retrospective observational study between January 2008 and December 2015 in a French colposcopic referral academic hospital. The maternity ward attached to the colposcopy clinic was also the obstetrical referral center for the region and carried out approximately 2500 deliveries per year. The aim of the study was to assess whether an age younger than 25 years at conization affected future pregnancy outcome as an independent factor. A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two groups were considered: patients younger than 25 years at the time of the loop electrosurgical excision procedure (n = 42) and 25 years or older (n = 73). Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.

Enrollment: 115 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female pregnant
• underwent loop electrosurgical excision procedure during the studied period
• delivered in their institution

Exclusion criteria

• patients having delivered elsewhere after loop electrosurgical excision procedure
• Early miscarriages (<14 weeks of amenorrhea )

Trial design

115 participants in 2 patient groups

< 25 years

Description:

42 patients younger than 25 years at the time of loop electrosurgical excision procedure

Treatment:

Other: loop electrosurgical excision procedure

> 25 years

Description:

73 patients 25 years or older at the time of loop electrosurgical excision procedure

Treatment:

Other: loop electrosurgical excision procedure