Impact of Amino Acids to Enhance Anabolism After Home-based Exercise (B2B)

University of Toronto

Status

Completed

Conditions

Metabolism

Amino Acids, Essential

Exercise

Treatments

Dietary Supplement: Branched-chain amino acid supplementation (BCAA)

Dietary Supplement: Isocaloric carbohydrate supplementation

Dietary Supplement: Novel essential amino acid supplementation

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT04850820

B2B

Details and patient eligibility

About

An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive. Amino acids are the building blocks of protein, and when consumed following resistance exercise, significantly improve NPB.

However, no study has investigated how a supplement of all of the essential amino acids (EAA) affects NPB following resistance exercise in a free-living, home-based setting, particularly when compared to a supplement of branched-chain amino acids (BCAA).

Therefore, the purpose of this study is to determine the impact of a novel EAA supplement on anabolism (e.g., NPB) as compared to BCAA and placebo supplements following home-based resistance exercise.

Enrollment

12 patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 18-35 years
Recreationally active; currently performing structured exercise (e.g., running, weight lifting, team-sport activity) at least 2 days per week

Exclusion criteria

Body Mass Index: >29.9kg/m^2
Inability to perform physical activity as determined by the Physical Activity Readiness Questionnaire
Inability to adhere to protocol guidelines (e.g., alcohol, habitual diet)
Regular tobacco use
Illicit drug use (e.g., growth hormone, testosterone)
Diagnosed medical condition under the care of a physician
Inability to abstain from supplements (e.g., protein, creatine, HMB, BCAA, phosphatidic acid) at least three weeks before and during trials
Individuals on any medications known to affect protein metabolism (e.g., corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

12 participants in 4 patient groups, including a placebo group

Novel essential amino acid supplementation (EAA+)

Experimental group

Description:

Arm will investigate the effect of a novel essential amino acid-based formula (essential amino acids enriched with active botanical compounds; EAA+) developed by Iovate Health Sciences International Inc. on post-exercise anabolism. The formulation was recently granted a Natural Product Number (NPN: 80087022) and approved by the Natural and Non-prescription Health Products Directorate of Health Canada.

Treatment:

Dietary Supplement: Novel essential amino acid supplementation

Branched-chain amino acid supplementation (BCAA)

Active Comparator group

Description:

Arm will used a branched-chain amino acid supplement developed by Iovate Health Sciences International Inc. to compare with the experimental arm after exercise.

Treatment:

Dietary Supplement: Branched-chain amino acid supplementation (BCAA)

Isocaloric carbohydrate supplementation

Placebo Comparator group

Description:

Carbohydrate supplement that is isocaloric to the EAA+ supplement and designed to function as a placebo to the experimental arm after exercise.

Treatment:

Dietary Supplement: Isocaloric carbohydrate supplementation

Rested control

Other group

Description:

Carbohydrate supplement that is isocaloric to the EAA+ supplement but consumed at rest to serve as the baseline control