Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults

Yonsei University

Status and phase: Completed; Phase 3

Conditions: Healthy Subjects

Treatments: Dietary Supplement: High LA; Dietary Supplement: Low LA

Study type: Interventional

Funder types: Other

Identifiers

NCT02753907

LA_fu

Details and patient eligibility

About

Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m^2 ≤ BMI < 30 kg/m^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a medium LA group (control group, n=50) maintained usual food intake; a high LA group (n=50) reduced 1/3 cup of cooked refined rice and consumed 9.9g of soy oil capsules daily as a supplement. Plasma fatty acids and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were measured at baseline and 8 week alongside other cardiovascular disease risk factors.

Enrollment: 150 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 30 to 65 years at beginning of study
• Subjects with BMI 18.5 to 30 kg/m^2

Exclusion criteria

• Use of any medication or supplements that alter lipid metabolism.
• Presence of dyslipidemia, diabetes mellitus, hypertension, liver disease, renal disease, chronic disease of the gastrointestinal tract, cerebrovascular disease, pancreatitis or cancer.
• Women who pregnant or lactating.
• Drug or alcohol abuse.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

150 participants in 3 patient groups

Low LA (linoleic acid)

Experimental group

Description:

Individuals who replaced 10 mL soy oil with one apple

Treatment:

Dietary Supplement: Low LA

Medium LA

No Intervention group

Description:

Individuals who maintained their usual food intake

High LA

Experimental group

Description:

Individuals who reduced 1/3 cup of cooked refined rice and consumed 9.9 g of soy oil as a supplement

Treatment:

Dietary Supplement: High LA