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Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults

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Yonsei University

Status and phase

Completed
Phase 3

Conditions

Healthy Subjects

Treatments

Dietary Supplement: High LA
Dietary Supplement: Low LA

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m^2 ≤ BMI < 30 kg/m^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a medium LA group (control group, n=50) maintained usual food intake; a high LA group (n=50) reduced 1/3 cup of cooked refined rice and consumed 9.9g of soy oil capsules daily as a supplement. Plasma fatty acids and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were measured at baseline and 8 week alongside other cardiovascular disease risk factors.

Enrollment

150 patients

Sex

All

Ages

30 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age 30 to 65 years at beginning of study
  • Subjects with BMI 18.5 to 30 kg/m^2

Exclusion criteria

  • Use of any medication or supplements that alter lipid metabolism.
  • Presence of dyslipidemia, diabetes mellitus, hypertension, liver disease, renal disease, chronic disease of the gastrointestinal tract, cerebrovascular disease, pancreatitis or cancer.
  • Women who pregnant or lactating.
  • Drug or alcohol abuse.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

150 participants in 3 patient groups

Low LA (linoleic acid)
Experimental group
Description:
Individuals who replaced 10 mL soy oil with one apple
Treatment:
Dietary Supplement: Low LA
Medium LA
No Intervention group
Description:
Individuals who maintained their usual food intake
High LA
Experimental group
Description:
Individuals who reduced 1/3 cup of cooked refined rice and consumed 9.9 g of soy oil as a supplement
Treatment:
Dietary Supplement: High LA

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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