Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment (CANVAS)

Capital Medical University

Status: Unknown

Conditions: Acute Stroke

Treatments: Other: Intravenous anesthetics; Other: Spontaneous breathing; Other: local anesthesia; Other: Controlled ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02677415

QML20150508

Details and patient eligibility

About

Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.

Enrollment: 640 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours.

Exclusion criteria

• Radiological ambiguity concerning infarction and vessel occlusion.
• Additional intracerebral hemorrhage.
• Posterior circulation infraction.
• Coma on admission (Glasgow coma score less than 8).
• NIHSS less than 10 or more than 35.
• Severe agitation or seizures on admission.
• Obvious loss of airway protective reflexes and/or vomiting on admission.
• Being intubated before treatment on admission.
• Known allergy to anesthetic or analgesic.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

640 participants in 2 patient groups

Local anesthesia

Other group

Description:

local anesthesia and spontaneous breathing will be maintained.

Treatment:

Other: Spontaneous breathing

Other: local anesthesia

General anesthesia

Other group

Description:

Intravenous anesthetics and controlled ventilation will be used .

Treatment:

Other: Intravenous anesthetics

Other: Controlled ventilation