Impact of Antenatal Corticosteroid Therapy on Postnatal Surfactant Use in Preterm Infants (CORISURF)

Hôpital NOVO

Status: Completed

Conditions: Hyaline Membrane Disease (HMD)

Treatments: Other: Impact of antenatal corticosteroid therapy on surfactants use postnatal

Study type: Observational

Funder types: Other

Identifiers

NCT05455879

CHRD0822

Details and patient eligibility

About

No study has shown that two doses of corticosteroids are more effective than a single dose in lung maturation and prevention of hyaline membrane disease (HMD) The aim of this study is to assess the impact of the number of doses on the severity of HMD.

Full description

Respiratory distress syndrome (RDS), formerly known as hyaline membrane disease, is a common problem in preterm infants. This disorder is caused primarily by deficiency of pulmonary surfactant in an immature lung. RDS is a major cause of morbidity and mortality in preterm infants.

Surfactant therapy has been shown to significantly reduce neonatal and infant mortality. Corticosteroids are given antenatal, and then surfactant is given, along with corticosteroids, postnatal.

A single course of corticosteroids is recommended for pregnant women between 24 weeks and 34 weeks of gestation who are at risk of preterm delivery within 7 days, including those with ruptured membranes and multiple pregnancies.

Betamethasone is recommended as the steroid of choice, to be administered in two doses of 12 mg given intramuscularly 24 hours apart.

Enrollment: 145 patients

Sex: All

Ages: Under 37 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Preterm infants ≤ 37 SA
• Hospitalized in the neonatal intensive care unit between January 2018 and December 2019
• Having received at least one dose of corticosteroids antenatal

Exclusion criteria

• Parental Opposition
• Congenital malformations that may cause neonatal respiratory distress.

Trial design

145 participants in 1 patient group

Impact of antenatal corticosteroid therapy on surfactants use postnatal

Description:

Intervention Description: Retrospective study on preterm infants to evaluate the impact of antenatal corticosteroid therapy on surfactants use postnatal

Treatment:

Other: Impact of antenatal corticosteroid therapy on surfactants use postnatal