Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation (A3)

Toulouse University Hospital

Status: Completed

Conditions: Kidney Transplant

Treatments: Other: Blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT03423901

RC31/17/0426

Details and patient eligibility

About

It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.

Full description

The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).

Enrollment: 58 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient receiving a KT and followed at least one year in Toulouse Hospital
• Patient who have signed informed consent
• > 18 years old

Exclusion criteria

• Patient under protective measures
• Patients treated for cancer, infectious or immune disease by molecules that could interfere with lymphocyte populations : Interleukin 6 (IL6) blockers, Programmed cell death 1(PD1) and the cytotoxic T-lymphocyte-associated antigen 4 (CTL4) blockers.
• Immunosuppressive treatments withdrawal - Patient in chronic dialysis
• Ongoing pregnancy or pregnancy in the past year
• Past of splenectomy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

58 participants in 3 patient groups

ABO/HLA incompatible KT

Experimental group

Description:

Blood sampling for descriptive analysis of clinical, biological and histological of 12 ABO and HLA incompatible kidney transplantation (KT)

Treatment:

Other: Blood sampling

ABO incompatible KT

Experimental group

Description:

Blood sampling for descriptive analysis of clinical, biological and histological of 28 ABO incompatible kidney transplantation

Treatment:

Other: Blood sampling

HLA incompatible KT

Experimental group

Description:

Blood sampling for descriptive analysis of clinical, biological and histological of 20 HLA incompatible kidney transplantation

Treatment:

Other: Blood sampling