Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure

Rijnstate Hospital

Status: Not yet enrolling

Conditions: Aorto Iliac Occlusive Disease; Blood Pressure

Treatments: Procedure: Stent placement

Study type: Interventional

Funder types: Other

Identifiers

NCT07070583

Blood pressure in AIOD

Details and patient eligibility

About

Hypertension is a major risk factor for a variety of cardiovascular diseases. When hypertension results from increased vascular resistance due to a narrowing of the descending aorta, it can be effectively treated with stenting. More recently, evidence suggest that stenting in more distal parts of the arterial vascular bed is also associated with a reduction in blood pressure. The investigators hypothesize that stenting of occlusions more distal of the descending aorta decreases the central blood pressure and afterload as reflected by NT-proBNP (N-terminal pro-Brain Natriuretic Peptide), a biomarker of intracardiac pressures and predictor of heart failure events. The goal of this pilot study is to prospectively investigate changes in blood pressure after stent placement in the aorto-iliac region.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years
• Singed informed consent
• Chronic occlusion in the infrarenal aorta and/or one or both common iliac arteries
• Total lesion length of ≥30mm
• Clinical indication for treatment of the pathology (Chronic limb threatening ischemia or disabling intermittent claudication not responding to supervised exercise training)

Exclusion criteria

• Patient is unable to understand the study requirements and/ or is unwilling to adhere to the follow-up
• Juxtarenal pathology (<2cm below the lowest renal artery)
• Acute occlusion of the target area (Acute Leriche Syndrome)
• Embolic disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Stent placement

Other group

Description:

Patients with an aorto-iliac occlusion will receive a stent, according to standard care

Treatment:

Procedure: Stent placement