Impact of Art Therapy on Brain Connectivity in Recent Post-Stroke Aphasia (ART-CONNECT)

Assistance Publique - Hôpitaux de Paris

Status

Completed

Conditions

Ischemic or Hemorrhagic Stroke

Treatments

Other: Art therapy and standard orthophonic rehabilitation

Study type

Interventional

Funder types

Other

Identifiers

NCT03820843

APHP180312

N° IDRCB: 2018-A02462-53 (Other Identifier)

Details and patient eligibility

About

A stroke located in the left parieto-temporal junction is associated, in aphasic right-handed patients, with a poor prognosis for language recovery. The role of the right hemisphere in recovering post-stroke aphasia is still controversial. Our hypothesis, based on recent work in imaging, is that early activation of the right hemisphere linked to the practice of the visual arts could facilitate language recovery in extended posterior left strokes that completely disrupt language areas.

Full description

The investigators will evaluate, at inclusion and at 6 weeks, the reorganization of functional and structural brain connectivity maps before and after rehabilitation of aphasia with art therapy and standard orthophonic rehabilitation versus a control group that received only standard orthophonic rehabilitation.

The investigators will include all consecutive patients with recent ischemic or hemorrhagic stroke with unilateral lesion(s) of the parieto-temporal left junction present on the Diffusion MRI (DWI) performed in acute phase at 24-48h.

All patients will undergo 2 MRI with tensor diffusion sequences (structural connectivity) and fMRI (functional magnetic resonance imaging) resting state sequences (functional connectivity) at inclusion and 6 weeks after rehabilitation with or without art therapy.

The investigators aimed to demonstrate that early activation of the right hemisphere related to the practice of the visual arts could facilitate the recovery of language in later strokes completely disrupting the language areas of the left hemisphere.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with recent ischemic or haemorrhagic stroke with unilateral lesion (s) of the parieto-temporal left junction present on the Diffusion MRI (DWI) performed in acute phase at 24-48h
Post stroke delay of 15 days to 2 months
Existence of moderate to severe phasic disorders on Aphasia Rapid Test score (ART, score> 6, scale of 26 items)
Patient able to read and understand French
Rightful
Normal and corrected vision and hearing
Absence of pre-existing degenerative neurological disorder
Patient having signed his consent
Age ≥ 18 years

Exclusion criteria

Patients with contraindications to MRI or claustrophobic
Patients under legal protection
Patients with behavioral disorders or disabling neurovisual disorders making participation in art therapy impossible
Mute patients, illiterate patients
Patients leaving the neurological SSR department prematurely
Patients not affiliated to a social security scheme
Pregnant or lactating women.