Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease

Sheba Medical Center

Status: Completed

Conditions: Nonalcoholic Fatty Liver Disease; Nonalcoholic Steatohepatitis

Treatments: Procedure: Sleeve gastrectomy

Study type: Observational

Funder types: Other

Identifiers

NCT01828528

SHEBA-12-0026-ZB-CTIL

Details and patient eligibility

About

The purpose of this study is to investigate the effect of weight loss rate on liver steatosis, steatohepatitis, fibrosis and cardiovascular risk at different stages before and after bariatric surgery. The investigators also aim to study the short-term effect of bariatric surgery on gastric cholecystokinin levels before and 10 days after the bariatric surgery.

Enrollment: 26 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20≤ age ≤80
• BMI>35kg/m2
• Men and women
• Fatty infiltration in liver ultrasonography

Exclusion criteria

• Alcohol drinking > 140g/week

• Presence of hepatitis B or C or HIV

• Known liver disease such as:

  1. Wilson's disease
  2. hemochromatosis
  3. α1-antitrypsin deficiency
  4. autoimmune liver disease
  5. primary biliary cirrhosis
  6. primary sclerosing cholangitis)

Trial design

26 participants in 1 patient group

NAFLD after SG

Description:

26 patients with NAFLD undergoing sleeve gastrectomy (SG).

Treatment:

Procedure: Sleeve gastrectomy