Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Blood Iron Isotope Enrichment

Treatments: Other: BAT 881; Other: 586/8; Other: 586/8x87 brown; Other: 586/8x87 white

Study type: Interventional

Funder types: Other

Identifiers

NCT01472484

lpa_586/8X87

Details and patient eligibility

About

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-pregnant, non-lactating women
• Between 18 and 40 years
• Below 65kg

Exclusion criteria

• Metabolic, chronic and gastro-intestinal disease
• Long-term medication
• Blood donation within 6 month before the study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 4 patient groups

lpa with high polyphenol

Experimental group

Treatment:

Other: 586/8x87 brown

lpa with low polyphenol

Experimental group

Treatment:

Other: 586/8x87 white

control bean with low polyphenol

Experimental group

Treatment:

Other: 586/8

control bean with high polyphenol

Experimental group

Treatment:

Other: BAT 881