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Impact of Beta-3 Agonist on Psychological Distress and Blood Flow of the Bladder in Women With Overactive Bladder Syndrome

F

Far Eastern Memorial Hospital

Status and phase

Withdrawn
Phase 4

Conditions

Overactive Bladder Syndrome

Treatments

Drug: Mirabegron 25mg

Study type

Interventional

Funder types

Other

Identifiers

NCT03695822
107009-F

Details and patient eligibility

About

We will get the impact of mirabegron on psychological distress, urethra and bladder blood flow and c reactive protein.

Full description

Background/Purpose: Pharmacologic treatments for female overactive bladder syndrome (OAB) include antimuscarinics and beta-agonist. Similar efficacy has been reported between antimuscarinics and beta-agonist. Antimuscarinics has been found to be beneficial for patients with psychological distress. However, the impact of mirabegron on psychological distress in female OAB remains unknown. In addition, some animal studies found that beta-3 agonist can improve arterial blood flow, bladder ischemia and might improve bladder function; however, there is still lack of human study. Besides, c reactive protein was found to be elevated in female OAB. Nonetheless there is no study mentioning about the impact of mirabegron on c reactive protein. Thus, the aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein.

Sex

Female

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All OAB female patients
  • >20 years

Exclusion criteria

  • Allergy to mirabegron, urinary tract infections

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

0 participants in 1 patient group

Mirabegron
Experimental group
Description:
OAB female patients who will receive beta-3 agonist (mirabegron 2 mg) treatment
Treatment:
Drug: Mirabegron 25mg

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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