Impact of Blood Salvage Therapy on Outcomes After Oncologic Liver Surgery

Université de Sherbrooke

Status: Completed

Conditions: Liver Neoplasms

Treatments: Procedure: Blood salvage therapy

Study type: Observational

Funder types: Other

Identifiers

NCT05164406

2018-2534

Details and patient eligibility

About

A before and after trial comparing the systematic use of blood salvage therapy with leucocyte filter during oncologic liver resections. Recurrence, survival, allogenic transfusion rates and surgical outcomes are compared with a representative historic cohort.

Full description

Blood salvage therapy in oncologic liver surgery is seldom used based on unproven concerns about the safety of the technique regarding potential cancer dissemination or recurrence. Nevertheless, the technique has proven advantages in other surgical settings regarding the allogenic transfusion outcomes. Allogenic blood transfusion has been scientifically proven to worsen prognosis in oncologic surgery. This study compares a cohort of patients systematically exposed the blood salvage therapy to one comparable cohort without the therapy and outcomes regarding transfusion rates, post-operative Hb measurement, recurrence, overall survival, and post-operative adverse events.

Enrollment: 106 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult Oncologic liver surgery scheduled in our institution

Exclusion criteria

• Condition precluding consent for trial Pregnancy

Trial design

106 participants in 2 patient groups

With blood salvage

Description:

Patients undergoing oncologic liver surgery with systematic use of blood salvage therapy

Treatment:

Procedure: Blood salvage therapy

Without blood salvage

Description:

Patients undergoing oncologic liver surgery without any blood salvage therapy