Impact of Bread Diet on Intestinal Dysbiosis and Irritable Bowel Syndrome Symptoms in Quiescent Ulcerative Colitis

Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta

Status

Completed

Conditions

Ulcerative Colitis in Remission

Treatments

Dietary Supplement: Treatment vs control bread

Study type

Interventional

Funder types

Other

Identifiers

NCT05656391

RTC-2017-CU

Details and patient eligibility

About

The present study aimed to compare the in vivo prebiotic properties of bread produced by traditional breadmaking techniques with that made using a modern breadmaking method on Irritable Bowel Syndrome-like symptoms in patients with quiescent Ulcerative Colitis. The expected outcome of the differential effects was a change in the faecal microbiome composition, which may indicate changes in the mucosa-associated microbiota.

Enrollment

31 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients diagnosed with ulcerative colitis according to established clinical and histological criteria as common clinical practice
Remission of ulcerative colitis defined as a total Mayo score ≤2 and faecal calprotectin values under 250 ng/g
Subjects aged over 18 years
Moderate-to-severe IBS-like symptomatology defined by Rome IV criteria and IBS Symptom Severity Score (IBS-SSS) > 175.

Exclusion criteria

Presence of flare-up of UC
Coeliac disease, colectomy, or intestinal resection
Antibiotic intake, prebiotic or probiotic treatment within 3 months before the study
Any malignancy, pregnancy, or breastfeeding
Intake of medication potentially influencing gastrointestinal function
Disability to give informed consent