Impact of Cancer on Memory Functioning: Understanding Disorders Using Approaches in Neuropsychology and Neuroimaging (CANMEM)

Centre Francois Baclesse

Status and phase: Terminated; Phase 2

Conditions: Breast Cancer; Healthy

Treatments: Procedure: cognitive tests and cerebral IRM

Study type: Interventional

Funder types: Other

Identifiers

NCT01332916

CANMEM

Details and patient eligibility

About

The purpose of this study is to investigate memory problems in patients with cancer.

Enrollment: 60 estimated patients

Sex: Female

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for patients:

• Patients aged 45 and over
• Patients from Grade 3 'end of primary schooling "minimum (scale Barbizet)
• Non-Metastatic Breast Cancer
• Adjuvant Chemotherapy: FEC, including Docetaxel Protocols
• No major cognitive impairment
• No previous neurological
• Lack of personality disorders and psychiatric disorders evolutionary
• Having signed the informed consent of study participation

Inclusion Criteria for control group:

• Women from the general population aged 45 and over, and matched in age and cultural level in patients
• Topics of Grade 3 'end of primary schooling "minimum (scale Barbizet)
• No prior cancer
• No major cognitive impairment
• No previous neurological
• Lack of personality disorders and psychiatric disorders evolutionary
• Participating in the IMAP Protocol No. ID-BCR: 2007-A00414-49 or IMAP+(n° ID RCB 2011-A01493-38)(see how the study below) have signed forms no objection and consent to study participation

Exclusion Criteria:

Traduction (français > anglais)

• Metastatic
• Cancer of the breast other than primitive
• Patients with paraneoplastic syndrome
• Patients under 45 years
• Patients whose achievement is below level 3 'end of primary schooling "(scale Barbizet)
• Patients with adjuvant chemotherapy is associated with targeted therapy
• Patients who have received other cancer treatments (chemotherapy or radiotherapy brain)
• Contraindication to the implementation of an MRI (claustrophobia, metal objects in the body)
• disorders of higher functions existing in the administration of chemotherapy
• Neurologic earlier
• Pathology psychiatric evolutionary
• Refusal of participation
• Patients unable to meet the cognitive tests
• Drug use
• Heavy drinking

Trial design

60 participants in 2 patient groups

patients aged 45 and over group

Experimental group

Description:

patients aged 45 and over with breast cancer and should receive an adjuvant chemotherapy

Treatment:

Procedure: cognitive tests and cerebral IRM

Procedure: cognitive tests and cerebral IRM

healthy volunteers (controls) aged 45 and over

Active Comparator group

Description:

healthy volunteers (controls) aged 45 and over

Treatment:

Procedure: cognitive tests and cerebral IRM

Procedure: cognitive tests and cerebral IRM