Impact of Cataract Surgery on Keratoplasty Graft Survival (IGREC)

Centre Hospitalier Universitaire de Besancon

Status: Completed

Conditions: Keratoconus; Cataract; Fuchs' Endothelial Dystrophy

Treatments: Procedure: Cataract surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02875145

API/2014/53

Details and patient eligibility

About

The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives.

Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term.

The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.

Enrollment: 453 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing keratoplasty
• Between january 1983 and december 2012
• Age 40 and older at the time of surgery

Exclusion criteria

• Cataract surgery prior to the keratoplasty
• Systemic inflammatory disease
• Previous history of uveitis

Trial design

453 participants in 2 patient groups

Keratoplasty with cataract surgery

Description:

Patients who underwent keratoplasty who also underwent a cataract surgery during follow up.

Treatment:

Procedure: Cataract surgery

Keratoplasty without cataract surgery

Description:

Patients who underwent keratoplasty who never underwent cataract surgery.