Impact of Catecholamine Spill-over on Outcome After RDN and EP Ablation (RDN-Cath-1)

University of Witten/Herdecke

Status: Unknown

Conditions: Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT01875809

RDN-Cathecholamines-1

Details and patient eligibility

About

Despite a rapidly increasing number of renal denervation (RDN) procedures, only little is known regarding the patient or procedural characteristics influencing the outcome. None of the detectable variables like number of ablation points, temperature rise, impedance drop, have been shown to correlate with the blood pressure (BP) reduction. In this study, the investigators assess different patient and procedural characteristics, like exact patient medication, stress hormones, heart rate variability, and focus on the change of the catecholamine spill-over, and the impact on BP and heart rate after RDN and after EP ablation. The investigators hypothesize the correlation between reduction of catecholamine spill-over due to denervation and the BP reduction. In this study, the investigators will assess 40 patients undergoing RDN and 40 patients undergoing EP ablation.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• medically-indicated renal denervation
• Age over 18 years
• written informed consent

Exclusion criteria

• pregnancy
• expected compliance problems
• current participation in other studies

Trial design

80 participants in 2 patient groups

Renal denervation (RDN)

Description:

Change of catecholamine spill-over during RDN

Electrophysiology (EP) Ablation

Description:

Change of catecholamine spill-over during EP ablation