Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy

Universitätsklinikum Köln

Status: Completed

Conditions: Reduced Biventricular Pacing; Systolic Heart Failure; Cardiac Resynchronization Therapy; Ventricular Premature Complexes; Ventricular Tachycardia

Treatments: Procedure: Catheter ablation of ventricular arrhythmia; Drug: Intensified medical therapy

Study type: Observational

Funder types: Other

Identifiers

NCT04065893

CRT-Bivent.

Details and patient eligibility

About

Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.

Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.

Enrollment: 65 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• reduced biventricular pacing <98% due to ventricular arrhythmia

Exclusion criteria

• reduced biventricular pacing <98% due to other cause
• age <18
• pregnancy

Trial design

65 participants in 2 patient groups

Catheter ablation group

Description:

Patients with reduced biventricular pacing due to PVC or VT receiving catheter ablation of PVC/VT according to guidelines and clinical practices

Treatment:

Procedure: Catheter ablation of ventricular arrhythmia

Medical treatment group

Description:

Patients with reduced biventricular pacing due to PVC or VT receiving intensified medical therapy (antiarrhythmics/betablocker) according to guidelines and clinical practices

Treatment:

Drug: Intensified medical therapy