Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System (CaffeineHSC)

Jasmin Rettkowski

Status

Not yet enrolling

Conditions

Healthy Adults; Hematopoietic System; Caffeine

Treatments

Other: Caffeine (200 mg)

Study type

Interventional

Funder types

Other

Identifiers

NCT07193264

2025-00914

Details and patient eligibility

About

This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults.

The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake.

The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Able to give consent.
Healthy adults aged ≥ 18 years.
Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months.
Willingness to comply with fasting requirements and study procedures.

Exclusion criteria

Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome).
Personal history of cancer.
Personal history of hematological disorders.
History of radiation therapy.
Known caffeine hypersensitivity or intolerance.
Known immunosuppression.