Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia

St. Justine's Hospital

Status: Completed

Conditions: Anesthesia, General; Infant

Treatments: Procedure: EtCO2 modification

Study type: Interventional

Funder types: Other

Identifiers

NCT03567031

#2017-1309

Details and patient eligibility

About

The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.

Full description

The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.

Enrollment: 60 patients

Sex: All

Ages: Under 6 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age < or = 6 months
• ASA class < or = 3
• General anesthesia required for surgery

Exclusion criteria

• No parental consent
• Emergency surgery
• Preexisting neurological condition
• Hemodynamic instability
• Preexisting hypoxemia and/or hypercapnia
• Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

60 participants in 1 patient group

Main Arm

Experimental group

Description:

In each patient, under ongoing standard general anesthesia in a stable state, EtCO2 is manually modified to reach predefined values, and after waiting until cerebral blood flow has reached steady state, NIRS and DTC values are noted.

Treatment:

Procedure: EtCO2 modification