Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

Yong Seog Oh

Status and phase: Completed; Phase 4

Conditions: Pericardial Effusion

Treatments: Drug: Colchicine

Study type: Interventional

Funder types: Other

Identifiers

NCT02260206

colchicine

Details and patient eligibility

About

The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

Full description

RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation.

Exclusion criteria

• Hypersensitivity on Colchicine
• The existence of intra-cardiac thrombus on trans-esophageal echocardiography
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Colchicine

Experimental group

Description:

Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation

Treatment:

Drug: Colchicine

No intervention

No Intervention group

Description:

No intervention