Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI (CBI)
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Details and patient eligibility
About
Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- MCI diagnosis (can be self referral, will determine eligibility at baseline)
Exclusion criteria
- Dementia diagnosis
- Head trauma
- Neuro/psychiatric disorders
- Current substance dependence
- Sensory/mobility deficits
- No more than 1 hour of purposeful, aerobic activity/week
- Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)
Trial design
Primary purpose
Allocation
Interventional model
Masking
52 participants in 3 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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