Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients

Technical University of Munich

Status: Completed

Conditions: Oral Lichen Planus

Treatments: Device: CO2-Laser Treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT02154607

TechnischeUM

Details and patient eligibility

About

Oral Lichen Planus (OLP) is a common condition with its erosive variant occasionally presenting a management challenge to the clinician. In addition it can have debilitating consequences on the patients' quality of life. The malignant transformation of OLP has been well documented. The aims of this work were to measure the number of patients developing malignant transformationof OLP to squamous cell carcinoma (SCC) comparing patients undergoing traditional symptomatic treatments with those patients that were treated by CO2 laser from 2004 - 2011. Outcome measures were rated by incisional biopsy (histology Report).

Enrollment: 263 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Oral lichen planus
• Histological confirmation of diagnosis
• Patient willing for treatment

Exclusion criteria

• Patient just does not want to participate as control/study group

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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263 participants in 2 patient groups

Symptomatic treatment

No Intervention group

Description:

Symptomatic analgetic Treatment only was performed without any Manipulation of OLP lesions.

CO2-Laser Treatment

Active Comparator group

Description:

CO2-Laser Vaporisation was performed of OLP lesions under local anaesthesia.

Treatment:

Device: CO2-Laser Treatment