Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Acute Asthma

Treatments: Device: Continuous positive airway pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT01403467

MURA2009/1239 (Other Identifier)

02-52-28

Details and patient eligibility

About

This current study aimed to demonstrate the effectiveness of the addition of CPAP to the current conventional therapy in terms of airway obstruction improvement in acute asthma patients.

Full description

Continuous positive airway pressure (CPAP) is widely used in providing ventilator support. However, its role in an acute asthmatic attack is uncertain. The purpose of this study was to compare the efficacy of CPAP when used in addition to conventional therapy with conventional therapy alone in the management of acute asthma exacerbation.

Enrollment: 86 patients

Sex: All

Ages: 19 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged over 18 years
• known asthmatic patients visiting ED with acute exacerbation
• had given their written informed consent.

Exclusion criteria

• smoking history
• chronic obstructive pulmonary disease
• required intubation
• instability of hemodynamic or arrhythmia
• unable to perform PEFR
• facial abnormality
• pulmonary infiltration
• pregnancy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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86 participants in 1 patient group

NIPPV

Experimental group

Treatment:

Device: Continuous positive airway pressure